منابع مشابه
NaNog: A pluripotency homeobox (master) molecule
One of the most intriguing aspects of cell biology is the state of pluripotency, where the cell is capable of self-renewal for as many times as deemed "necessary", then at a specified time can differentiate into any type of cell. This fundamental process is required during organogenesis in foetal life and importantly during tissue repair in health and disease. Pluripotency is very tightly regul...
متن کاملMining NANOG Mailing List∗
It had been shown that the misbehaviors by few malicious, compromised or misconfigured BGP routers could lead to serious outages in Internet. This failing becomes progressively crucial as the recent prosper of outage-sensitive applications such as Voice over IP, streaming media, and video conferencing. To address these misbehaviors, previous work mainly focus on distributedly detect or prevent ...
متن کاملNanog Heterogeneity: Tilting at Windmills?
Fluctuating expression of transcription factors in embryonic stem cells is an alluring observation, but, as outlined by two articles in this issue, appearances can be misleading.
متن کاملOCT4/SOX2-independent Nanog autorepression modulates heterogeneous Nanog gene expression in mouse ES cells.
NANOG, OCT4 and SOX2 form the core network of transcription factors supporting embryonic stem (ES) cell self-renewal. While OCT4 and SOX2 expression is relatively uniform, ES cells fluctuate between states of high NANOG expression possessing high self-renewal efficiency, and low NANOG expression exhibiting increased differentiation propensity. NANOG, OCT4 and SOX2 are currently considered to ac...
متن کاملEsrrb Is a Direct Nanog Target Gene that Can Substitute for Nanog Function in Pluripotent Cells
Embryonic stem cell (ESC) self-renewal efficiency is determined by the level of Nanog expression. However, the mechanisms by which Nanog functions remain unclear, and in particular, direct Nanog target genes are uncharacterized. Here we investigate ESCs expressing different Nanog levels and Nanog(-/-) cells with distinct functionally inducible Nanog proteins to identify Nanog-responsive genes. ...
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ژورنال
عنوان ژورنال: Atlas of Genetics and Cytogenetics in Oncology and Haematology
سال: 2012
ISSN: 1768-3262
DOI: 10.4267/2042/48149